Gene Mb3444c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB3 (IMP DEHYDROGENASE) (INOSINIC ACID DEHYDROGENASE) (INOSINATE DEHYDROGENASE) (IMP OXIDOREDUCTASE) (INOSINE-5'-MONOPHOSPHATE OXIDOREDUCTASE) (IMPDH) (IMPD) |
| Comments | Mb3444c, guaB3, len: 375 aa. Equivalent to Rv3410c,len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 375 aa overlap). Probable guaB3,inosine-5'-monophosphate (IMP) dehydrogenase (EC 1.1.1.205), equivalent to Q49721|YY10_MYCLE|ML0388|B1620_C2_193 HYPOTHETICAL 38.9 KDA PROTEIN from Mycobacterium leprae (375 aa), FASTA scores: opt: 2182, E(): 9.5e-122, (90.6% identity in 373 aa overlap). Highly similar to Q9RHY9 GUAB ORF GENES FOR IMP DEHYDROGENASE, HYPOTHETICAL PROTEIN from Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) (376 aa), FASTA scores: opt: 1490, E(): 7.6e-81, (61.0% identity in 382 aa overlap); Q9L0I6|SCD63.03 PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE from Streptomyces coelicolor (374 aa), FASTA scores: opt: 1275, E(): 3.8e-68, (52.95% identity in 372 aa overlap); P73853|GUAB|SLR1722 IMP DEHYDROGENASE SUBUNIT from Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores: opt: 882, E(): 6.7e-45, (41.3% identity in 373 aa overlap); and similar to other inosine-5'-monophosphate dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from Haemophilus influenzae (488 aa), FASTA scores: opt: 267,E(): 1.8e-08, (34.25% identity in 216 aa overlap); etc. Also highly similar to the C-terminus of Q50753|GUAA/B HOMOLOGY TO Mycobacterium leprae GUAA (FRAGMENT) from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 506, E(): 4.6e-23, (85.05% identity in 87 aa overlap). SIMILAR TO OTHER EUKARYOTIC AND PROKARYOTIC IMPDH AND TO GMP REDUCTASE. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3781411 | 3782538 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3444c|guaB3
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG
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