Gene Mb3498c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namemhpE
Gene length1011 bp
IdentifierMb3498c
Location 3833769 bp
Protein summary information
Molecular mass36297.1 Da
Isoelectric point5.3616
Protein length336 amino acids
Orthologs
M. tuberculosis H37RvRv3469c
M. tuberculosis MTBC0mtbc0_003686
Cross-references
InterProIPR000891, IPR013785, IPR017629
UniProtKB/TrEMBLQ7TWG2
SWISS-MODELA0A1R3Y4Y7
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE (HOA)
CommentsMb3498c, mhpE, len: 336 aa. Equivalent to Rv3469c,len: 336 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 336 aa overlap). Probable mhpE,4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% identity in 332 aa overlap); Q9X9Q0|NIKB NIKB PROTEIN (see first citation below) from Streptomyces tendae (357 aa),FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in 339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp. strain KKS102 (352 aa), FASTA scores: opt: 549, E(): 9.9e-27, (31.2% identity in 314 aa overlap); Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa), FASTA scores: opt: 543, E(): 2.3e-26, (30.7% identity in 319 aa overlap); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 517, E(): 9.1e-25, (31.75% identity in 312 aa overlap); etc. Also similar to P71867|MTCY03C7.22|Rv3534c HYPOTHETICAL 36.4 KDA PROTEIN from Mycobacterium tuberculosis (346 aa),FASTA scores: E(): 7.5e-24, (31.9% identity in 310 aa overlap).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38337693834779-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3498c|mhpE
MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA
Bibliography
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