Gene Mb3539c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE ACETOHYDROXYACID SYNTHASE ILVX (ACETOLACTATE SYNTHASE) |
| Comments | Mb3539c, ilvX, len: 515 aa. Equivalent to Rv3509c,len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 515 aa overlap). Probable ilvX,acetohydroxyacid synthase (EC 4.1.3.18), equivalent to Mycobacterium leprae protein described as Acetolactate synthase I, valine sensitive, large subunit (EC 4.1.3.18) Q49865|ILVX|ILVI1|B229_C3_222 (515 aa), FASTA scores: opt: 2762, E(): 8.8e-145, (82.9% identity in 515 aa overlap). Also similar to various enzymes (principally acetohydroxyacid/acetolactate synthases) e.g. Q9AB41|CC0393 THIAMINE-PYROPHOSPHATE-REQUIRING ENZYME from Caulobacter crescentus (512 aa), FASTA scores: opt: 1572,E(): 2.8e-79, (50.95% identity in 514 aa overlap); BAB50432|MLL3567 ACETOLACTATE SYNTHASE I from Rhizobium loti (Mesorhizobium loti) (517 aa), FASTA scores: opt: 1440, E(): 5.2e-72, (47.9% identity in 548 aa overlap); P20906|MDLC_PSEPU BENZOYLFORMATE DECARBOXYLASE (EC 4.1.1.7) from Pseudomonas putida (528 aa), FASTA scores: opt: 356, E(): 2.5e-12, (28.1% identity in 530 aa overlap); Q9L123|SC6D11.33c PUTATIVE DECARBOXYLASE from Streptomyces coelicolor (526 aa), FASTA scores: opt: 325,E(): 1.3e-10, (33.2% identity in 530 aa overlap); Q9RDF9|SCC57A.40c PUTATIVE ACETOLACTATE SYNTHASE from Streptomyces coelicolor (564 aa), FASTA scores: opt: 304,E(): 1.9e-09, (28.55% identity in 550 aa overlap); P94783 VALINE-SENSITIVE ACETOHYDROXY ACID SYNTHASE from Citrobacter freundii (561 aa), FASTA scores: opt: 278,E(): 5.1e-08, (25.8% identity in 550 aa overlap); Q42767|AHAS ACETOHYDROXYACID SYNTHASE (EC 4.1.3.18)from Gossypium hirsutum (Upland cotton) (659 aa), FASTA scores: opt: 278, E(): 5.8e-08, (26.15% identity in 558 aa overlap); etc. Note that other Mycobacterium tuberculosis proteins, e.g. O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c,show better similarity to Acetolactate synthase I. SIMILAR TO OTHER ENZYMES WHICH REQUIRE TPP. COFACTOR: THIAMIN PYROPHOSPHATE (BY SIMILARITY). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3881114 | 3882661 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3539c|ilvX
MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCWSDGAHAAAGVPAQAAAAPVDVGPVAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAGARSPVSFFAYPGMPSDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVAGASRPQLPTGDLTSVSAADVVGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDRPVLCLESDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAGSDPGPKALDLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPGPHLIDVVVPSLVG
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