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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA)
CommentsMb3564c, -, len: 346 aa. Equivalent to Rv3534c,len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 346 aa overlap). Probable 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-), highly similar to others e.g. P51015|BPHI_PSESP from Pseudomonas sp. strain LB400 (346 aa), FASTA scores: opt: 1150, E(): 2.3e-61, (51.35% identity in 331 aa overlap); Q52040|BPHX3 from Pseudomonas pseudoalcaligenes (346 aa), FASTA scores: opt: 1147, E(): 3.5e-61, (51.35% identity in 331 aa overlap); P51017|NAHM_PSEPU from Pseudomonas putida (346 aa), FASTA scores: opt: 1145, E(): 4.7e-61, (50.9% identity in 330 aa overlap) (see citation below); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain K12 (337 aa), FASTA scores: opt: 1133, E(): 2.4e-60,(52.0% identity in 327 aa overlap); O24833|ATDG from Acinetobacter sp (340 aa), FASTA scores: opt: 1132, E(): 2.7e-60, (50.45% identity in 331 aa overlap); etc. Note that also highly similar to Q9ZI56|NAHM 2-OXO-4-HYDROXYPENTANOATE ALDOLASE from Pseudomonas stutzeri (Pseudomonas perfectomarina) (346 aa) FASTA scores: opt: 1168, E(): 2e-62, (51.05% identity in 331 aa overlap) (see citation below).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS39157673916807-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3564c|hsaf
MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
      
Bibliography
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