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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductLYSYL-TRNA SYNTHETASE 1 LYSS (LYSINE--TRNA LIGASE 1) (LYSRS 1) (LYSINE TRANSLASE)
CommentsMb3629c, lysS, len: 505 aa. Equivalent to Rv3598c,len: 505 aa, from Mycobacterium tuberculosis H37Rv,(100.0% identity in 505 aa overlap). Probable lysS,lysyl-tRNA synthetase 1 (EC 6.1.1.6), equivalent to P46861|SYK_MYCLE|LYSS|ML0233 LYSYL-TRNA SYNTHETASE from Mycobacterium leprae (507 aa), FASTA scores: opt: 2835,E(): 4.5e-172, (85.45% identity in 501 aa overlap); and similar with C-terminal part of Q9CC23|LYSX|ML1393 C-TERM LYSYL-TRNA SYNTHASE from Mycobacterium leprae (1039 aa) FASTA scores: opt: 1257, E(): 7.6e-72, (44.55% identity in 505 aa overlap). Also similar to others e.g. P37477|SYK_BACSU|LYSS from Bacillus subtilis (499 aa) FASTA scores: opt: 1294, E(): 1.9e-74, (42.35% identity in 498 aa overlap); Q9RHV9|SYK_BACST|LYSS from Bacillus stearothermophilus (494 aa), FASTA scores: opt: 1258, E(): 3.5e-72, (41.15% identity in 498 aa overlap); Q9PEB6|SYK_XYLFA|LYSS|XF1112 from Xylella fastidiosa (506 aa), FASTA scores: opt: 1228, E(): 2.9e-70, (43.05% identity in 495 aa overlap); etc. Also similar to P94974|SYK2_MYCTU|LYSS2|LYSX|Rv1640c|MTCY06H11.04c LYSYL-TRNA SYNTHETASE 2 from Mycobacterium tuberculosis (1172 aa), FASTA scores: opt: 1295, E(): 3.3e-74, (45.65% identity in 506 aa overlap). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASE FAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS39846643986181-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3629c|lysS
MSAADTAEDLPEQFRIRRDKRARLLAQGRDPYPVAVPRTHTLAEVRAAHPDLPIDTATEDIVGVAGRVIFARNSGKLCFATLQDGDGTQLQVMISLDKVGQAALDAWKADVDLGDIVYVHGAVISSRRGELSVLADCWRIAAKSLRPLPVAHKEMSEESRVRQRYVDLIVRPEARAVARLRIAVVRAIRTALQRRGFLEVETPVLQTLAGGAAARPFATHSNALDIDLYLRIAPELFLKRCIVGGFDKVFELNRVFRNEGADSTHSPEFSMLETYQTYGTYDDSAVVTRELIQEVADEAIGTRQLPLPDGSVYDIDGEWATIQMYPSLSVALGEEITPQTTVDRLRGIADSLGLEKDPAIHDNRGFGHGKLIEELWERTVGKSLSAPTFVKDFPVQTTPLTRQHRSIPGVTEKWDLYLRGIELATGYSELSDPVVQRERFADQARAAAAGDDEAMVLDEDFLAALEYGMPPCTGTGMGIDRLLMSLTGLSIRETVLFPIVRPHSN
      
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