Gene Mb3721c
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE GLYCEROL KINASE GLPKB [SECOND PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK) |
| Comments | Mb3721c, glpKb, len: 326 aa. Equivalent to 3' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 326 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120,E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606,E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108,(54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 4075549 | 4076529 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Bibliography
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