Gene Mb3747
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE FATTY ACID SYNTHASE |
| Comments | Mb3747, -, len: 420 aa. Equivalent to Rv3720, len: 420 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 420 aa overlap). Possible fatty-acyl-phospholipid synthase (EC 2.1.1.-), equivalent to Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa) HYPOTHETICAL PROTEIN from Mycobacterium leprae (420 aa) FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity in 420 aa overlap). Also similar (especially at the C-terminus) to various fatty-acid synthases (principally cyclopropane-fatty-acyl-phospholipid synthases (EC 2.1.1.79)) and hypothetical proteins e.g. Q9KZ58|SCE25.32c PUTATIVE FATTY ACID SYNTHASE from Streptomyces coelicolor (438 aa), FASTA scores: opt: 1101, E(): 5.5e-63, (46.1% identity in 425 aa overlap); P31049|YLP3_PSEPU HYPOTHETICAL 44.7 KDA PROTEIN from Pseudomonas putida (394 aa), FASTA scores: opt: 810, E(): 2.1e-44, (46.4% identity in 293 aa overlap); Q9HT28|PA5546 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (394 aa), FASTA scores: opt: 804, E(): 5.2e-44, (40.7% identity in 371 aa overlap); Q9RSD7|DR2187 PUTATIVE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Deinococcus radiodurans (462 aa), FASTA scores: opt: 747,E(): 2.6e-40, (35.95% identity in 409 aa overlap); BAB50831|Q98ET6|MLL4091 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE from Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa overlap); P30010|CFA_ECOLI|CDFA|B1661 CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIP SYNTHASE from Escherichia coli strain K12 (381 aa), FASTA scores: opt: 530, E(): 1.7e-26, (33.65% identity in 312 aa overlap); etc. Also similar to other proteins from Mycobacterium tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa); P96911|Rv0621|MTCY20H10 (354 aa); O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 4101196 | 4102458 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3747|Mb3747
MAEILEIFTATGQHPLKFTAYDGSTAGQDDATLGLDLRTPRGATYLATAPGELGLARAYVSGDLQAHGVHPGDPYELLKTLTERVDFKRPSARVLANVVRSIGVEHILPIAPPPQEARPRWRRMANGLLHSKTRDAEAIHHHYDVSNNFYEWVLGPSMTYTCAVFPNAEASLEQAQENKYRLIFEKLRLEPGDRLLDVGCGWGGMVRYAARRGVRVIGATLSAEQAKWGQKAVEDEGLSDLAQVRHSDYRDVAETGFDAVSSIGLTEHIGVKNYPFYFGFLKSKLRTGGLLLNHCITRHDNRSTSFAGGFTDRYVFPDGELTGSGRITTEIQQVGLEVLHEENFRHHYAMTLRDWCGNLVEHWDDAVAEVGLPTAKVWGLYMAASRVAFERNNLQLHHVLATKVDPRGDDSLPLRPWWQP
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