Gene Mb3780 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametyrA
Gene length906 bp
IdentifierMb3780
Location 4136715 bp
Protein summary information
Molecular mass30991.1 Da
Isoelectric point6.1136
Protein length301 amino acids
Orthologs
M. tuberculosis H37RvRv3754
M. tuberculosis MTBC0mtbc0_003978
Cross-references
InterProIPR003099, IPR008927, IPR016040
UniProtKB/TrEMBLQ7TVR9
SWISS-MODELA0A1R3Y570
General annotation
TypeCDS
FunctionUnknown
ProductPREPHENATE DEHYDROGENASE TYRA (PDH) (HYDROXYPHENYLPYRUVATE SYNTHASE)
CommentsMb3780, tyrA, len: 301 aa. Equivalent to Rv3754,len: 301 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 301 aa overlap). Probable tyrA,prephenate dehydrogenase (EC 1.3.1.12), equivalent, but shorter 27 aa, to Q9CB34|ML2472 POSSIBLE PREPHENATE DEHYDROGENASE from Mycobacterium leprae (327 aa) FASTA scores: opt: 1600, E(): 1.6e-89, (80.0% identity in 300 aa overlap). Also similar to many pephenate dehydrogenases e.g. Q9RND8|TYRA from Bordetella bronchiseptica (Alcaligenes bronchisepticus) (299 aa), FASTA scores: opt: 345, E(): 9.7e-14, (32.85% identity in 271 aa overlap); Q9RVA7|DR1122 from Deinococcus radiodurans (372 aa) FASTA scores: opt: 341, E(): 2e-13, (35.65% identity in 216 aa overlap); P20692|TYRA_BACSU from Bacillus subtilis (372 aa), FASTA scores: opt: 314, E(): 8.6e-12, (27.75% identity in 263 aa overlap); etc. Also similar to Q04983|TYRC_ZYMMO TYRC PROTEIN [INCLUDES: CYCLOHEXADIENYL DEHYDROGENASE AND PREPHENATE DEHYDROGENASE ACTIVITIES] from Zymomonas mobilis (293 aa), FASTA scores: opt: 290,E(): 2e-10, (30.15% identity in 239 aa overlap). Equivalent to AAK48225 from Mycobacterium tuberculosis strain CDC1551 (323 aa) but shorter 22 aa.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41367154137620+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3780|tyrA
MRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSPQ
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