Gene Mb3782c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproZ
Gene length720 bp
IdentifierMb3782c
Location 4138188 bp
Protein summary information
Molecular mass24181.9 Da
Isoelectric point9.8417
Protein length239 amino acids
Cross-references
InterProIPR000515
UniProtKB/TrEMBLQ7TVR7
SWISS-MODELA0A1R3Y551
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROZ
CommentsMb3782c, proZ, len: 239 aa. Equivalent to Rv3756c,len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 239 aa overlap). Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 402, E(): 1.9e-16, (32.0% identity in 203 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 385, E(): 1.8e-15, (30.2% identity in 222 aa overlap); P39775|O34657|OPUBD|PROZ|OPBD_BACSU CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (226 aa) FASTA scores: opt: 350, E(): 2e-13, (31.75% identity in 208 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41381884138907-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3782c|proZ
MNFLQQALSYLLTASNWTGPVGLAVRTCEHLEYTAVAVAASALIAVPVGLLIGHTGRGTLLVVGAVNGLRALPTLGVLLLGVLLFGLGLGPPLVALMLLGIPSLLASTYAGIASVDPLVVDAARAMGMTESQVLLRVEVPNALPLMLGGLRSATLQVVATATVAAYASLGGLGGYLIDGIKERRFHIALVGAMMVAALALTLDGLLALAGWVSVPGTGRMRKLAAVVDKPAAGGGHALR
Bibliography
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