Gene Mb3783c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproW
Gene length690 bp
IdentifierMb3783c
Location 4138904 bp
Protein summary information
Molecular mass24108.9 Da
Isoelectric point11.7261
Protein length229 amino acids
Orthologs
M. tuberculosis H37RvRv3757c
M. tuberculosis MTBC0mtbc0_003981
Cross-references
InterProIPR000515
UniProtKB/TrEMBLQ7TVR6
SWISS-MODELA0A1R3Y549
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROW
CommentsMb3783c, proW, len: 229 aa. Equivalent to Rv3757c,len: 229 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 229 aa overlap). Possible proW,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD PROTEIN (PROBABLE GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER) from Staphylococcus aureus (231 aa) FASTA scores: opt: 364, E(): 7.1e-15, (30.0% identity in 220 aa overlap); Q45461|OPBB_BACSU|OPUBB|PROW CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN (mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine) from Bacillus subtilis (217 aa), FASTA scores: opt: 348, E(): 6.2e-14, (31.05% identity in 206 aa overlap); O34878|OPCB_BACSU|OPUCB GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (217 aa), FASTA scores: opt: 343, E(): 1.2e-13, (30.1% identity in 206 aa overlap); O34742|OPCD_BACSU|OPUCD GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT SYSTEM PERMEASE PROTEIN from Bacillus subtilis (229 aa) FASTA scores: opt: 337, E(): 2.9e-13, (31.1% identity in 193 aa overlap); etc. COULD BELONG TO THE CYSTW SUBFAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41389044139593-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3783c|proW
MHYLMTHPGAAWALTVVHLRLSLLPVLIGLMSAVPLGLLVQRAPLLRRLTTATASVIFTIPSLALFVVLPLIIGTRILDEANVIVALAAYTTALLVRAVLEALDAVPAQVHDAATAIGYSRIAQMLKVELPLSIPVLVAGLRVVAVTNIAMVSVGSVIGIGGLGTWFTAGYQTNKSDQIVAGVVAMFLLAIVVDVVINLAGRLATPWERAPRAARRRRQVAAPITGGAR
Bibliography
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