Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
Productprobable two component transcriptional regulatory protein tcrx
CommentsMb3791c, -, len: 234 aa. Equivalent to Rv3765c,len: 234 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 234 aa overlap). Probable response regulator of a two-component regulatory system, highly similar to others e.g. Q9ADN7|2SC10A7.24 PUTATIVE TWO COMPONENT SYSTEM RESPONSE REGULATOR from Streptomyces coelicolor (271 aa), FASTA scores: opt: 1111, E(): 4.8e-63, (72.3% identity in 231 aa overlap); Q9F161 RESPONSE REGULATOR from Corynebacterium glutamicum (Brevibacterium flavum) (232 aa), FASTA scores: opt: 692,E(): 1.2e-36, (46.0% identity in 226 aa overlap); Q9KZU5|SCD84.23c PUTATIVE TWO-COMPONENT SYSTEN RESPONSE REGULATOR from Streptomyces coelicolor (248 aa), FASTA scores: opt: 674, E(): 1.7e-35, (44.05% identity in 236 aa overlap); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. Q50806|Rv1033c|MTCY10G2.16 RESPONSE REGULATOR HOMOLOG (257 aa), FASTA scores: opt: 947, E(): 1e-52, (59.5% identity in 232 aa overlap); P71814|Rv0757|MTCY369.02 PHOP-LIKE PROTEIN (247 aa) FASTA scores: opt: 829, E(): 2.8e-45, (54.65% identity in 225 aa overlap); O53894|Rv0981|MTV044.09 (230 aa), FASTA scores: opt: 662, E(): 9e-35, (44.65% identity in 224 aa overlap); and also similar to MTCY31_34; MTCY19H5_20; MTY13628_5; MTCY20G9_17; and to MLCB57_27 from Mycobacterium leprae; and MBY13627_3 from Mycobacterium bovis BCG. Equivalent to AAK48236 from Mycobacterium tuberculosis strain CDC1551 (286 aa) but shorter 52 aa. THE N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. SIMILAR TO BACTERIAL REGULATORY PROTEINS INVOLVED IN SIGNAL TRANSDUCTION.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41473744148078-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3791c|tcrx
MRRADGQPVTVLVVDDEPVLAEMVSMALRYEGWNITTAGDGSSAIAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVLLLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGAQLVVGDLVLDEDSHEVMRAGEPVSLTSTEFELLRFMMHNSKRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREPMIHTLRGAGYVLKPAR
      
Bibliography
No article yet recorded