Gene Mb3813
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | possible dtdp-glucose 4,6-dehydratase |
| Comments | Mb3813, rfbB, len: 326 aa. Equivalent to Rv3784,len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 326 aa overlap). Possible rfbB,dTDP-glucose 4,6-dehydratase (EC 4.2.1.46), similar to others e.g. Q9YCT1|APE1180 LONG HYPOTHETICAL DTDP-GLUCOSE 4,6-DEHYDRATASE from Aeropyrum pernix (330 aa) FASTA scores: opt: 598, E(): 3.7e-30, (34.9% identity in 315 aa overlap); O27817|MTH1789 DTDP-GLUCOSE 4,6-DEHYDRATASE from Methanothermobacter thermautotrophicus (336 aa) FASTA scores: opt: 587, E(): 1.8e-29, (34.9% identity in 315 aa overlap); Q9X5W0|GRSE TDP-GLUCOSE-4,6-DEHYDRATASE HOMOLOG from Streptomyces griseus (324 aa), FASTA scores: opt: 583, E(): 3.2e-29, (35.7% identity in 325 aa overlap); Q9K7J7|SPSJ|BH3364 SPORE COAT POLYSACCHARIDE SYNTHESIS (DTDP GLUCOSE 4, 6-DEHYDRATASE) from Bacillus halodurans (321 aa), FASTA scores: opt: 562, E(): 6.5e-28, (33.0% identity in 318 aa overlap); Q9UZH2|RFBB|PAB0785 DTDP-GLUCOSE 4,6-DEHYDRATASE from Pyrococcus abyssi (333 aa), FASTA scores: opt: 552, E(): 2.8e-27, (33.95% identity in 318 aa overlap); P27830|RFFG_ECOLI|B3788 DTDP-GLUCOSE 4,6-DEHYDRATASE from Escherichia coli strain K12 (355 aa), FASTA scores: opt: 401, E(): 7.5e-28, (31.3% identity in 348 aa overlap); etc. But also similar to several UDP-glucose 4-epimerases (EC 5.1.3.2) and other proteins e.g. O59375|PH1742 LONG HYPOTHETICAL UDP-GLUCOSE 4-EPIMERASE from Pyrococcus horikoshii (306 aa) FASTA scores: opt: 600, E(): 2.6e-30, (34.5% identity in 313 aa overlap); Q9ZGC7|LANH14 NDP-HEXOSE 4,6-DEHYDRATASE HOMOLOGfrom Streptomyces cyanogenus (326 aa), FASTA scores: opt: 593, E(): 7.6e-30, (36.45% identity in 321 aa overlap); Q57664|GALE_METJA|MJ0211 PUTATIVE UDP-GLUCOSE 4-EPIMERASE from Methanococcus jannaschii (305 aa) FASTA scores: opt: 575, E(): 9.6e-29, (32.6% identity in 313 aa overlap); etc. SEEMS TO BELONG TO THE SUGAR EPIMERASE FAMILY, DTDP-GLUCOSE DEHYDRATASE SUBFAMILY. Note that previously known as epiB. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 4166551 | 4167531 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3813|rfbB
MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTLRGQAINFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPADISLAKSIGFQPQVEIWDGIDRYINWAKDQPQYPYEQDGFSGSSVL
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