Gene Mb3946 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb3946
Gene length1221 bp
IdentifierMb3946
Location 4337152 bp
Protein summary information
Molecular mass43911.5 Da
Isoelectric point6.8457
Protein length406 amino acids
Orthologs
M. tuberculosis MTBC0mtbc0_004149
M. tuberculosis H37RvRv3915
Cross-references
InterProIPR002477, IPR002508
UniProtKB/TrEMBLQ7TVC7
SWISS-MODELA0A1R3Y5M1
General annotation
TypeCDS
FunctionUnknown
Productprobable peptidoglycan hydrolase
CommentsMb3946, -, len: 406 aa. Equivalent to Rv3915, len: 406 aa, from Myobacterium tuberculosis strain H37Rv,(100.0% identity in 406 aa overlap). Probable hydrolase (EC 3.-.-.-), equivalent to Q9CCX8|ML2704 PUTATIVE HYDROLASE from Mycobacterium leprae (406 aa) FASTA scores: opt: 2341, E(): 2.7e-138, (86.95% identity in 406 aa overlap); the N-terminal end is highly similar to Q59535 N-ACETYMURAMYL-L-ALANINE AMIDASE (EC 3.5.1.28) from Mycobacterium leprae (205 aa), FASTA scores: opt: 1046,E(): 5.7e-58, (84.85% identity in 185 aa overlap). Also similar to other hydrolases (especially amidases (EC 3.5.-.-)) e.g. C-terminal end of Q9K6R3|LYTC|BH3665 N-ACETYLMURAMOYL-L-ALANINE AMIDASE (MAJOR AUTOLYSIN) from Bacillus halodurans (588 aa), FASTA scores: opt: 363, E(): 4.3e-15, (33.15% identity in 356 aa overlap); Q9PKC7|TC0539 PUTATIVE N-ACETYLMURAMOYL-L-ALANINE AMIDASE from Chlamydia muridarum (268 aa), FASTA scores: opt: 285,E(): 1.6e-10, (26.05% identity in 242 aa overlap) (RV3915 product appears longer 127 aa); Q9S596|PDCA PENICILLIN-RESISTANT DD-CARBOXYPEPTIDASE (EC 3.4.-.-) from Myxococcus xanthus (302 aa), FASTA scores: opt: 270, E(): 1.5e-09, (39.85% identity in 158 aa overlap); etc. Note that previously known as cwlM.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS43371524338372+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3946|Mb3946
MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLYFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETHLSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRVHGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAGRLGGS
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