Gene Rv0608 in Mycobacterium tuberculosis H37Rv
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namevapB28
Gene length246 bp
IdentifierRv0608
Location 703244 bp
Protein summary information
Molecular mass8813.12 Da
Isoelectric point10.3541
Protein length81 amino acids
Structural information
PFAMO07770
Orthologues
M. bovisMb0624
Cross-references
UniProtP9WJ39
TB databaseRv0608
Interacting Drugs/Compounds
TDR TargetsLink
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible antitoxin VapB28
CommentsRv0608, (MTCY19H5.14c), len: 81 aa. Possible vapB28, antitoxin, part of toxin-antitoxin (TA) operon with Rv0609, see Arcus et al. 2005. Similar to several others e.g. Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores: opt: 159, E(): 1.2e-09, (43.0% identity in 86 aa overlap); Rv2760c (89 aa); Rv1740 (70 aa), etc. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Functional categoryVirulence, detoxification, adaptation
ProteomicsTranslational start site supported by proteomics data (See Kelkar et al., 2011).
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS703244703489+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv0608|vapB28
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA
Bibliography