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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
intermediary metabolism and respiration
regulatory proteins
conserved hypotheticals
lipid metabolism
General annotation
FunctionFunction unknown
ProductPE-PGRS family protein PE_PGRS25
CommentsRv1396c, (MTCY21B4.13c), len: 576 aa. PE_PGRS25, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002), strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, similar to other PGRS-type sequences. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Functional categoryPe/ppe
TranscriptomicsmRNA identified by RT-PCR (see Banu et al., 2002).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1396c|PE_PGRS25