Gene Rv1607
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Involved in transport of ions (presumably calcium) across the membrane. Responsible for the translocation of the substrate across the membrane. |
| Product | Probable ionic transporter integral membrane protein ChaA |
| Comments | Rv1607, (MTV046.05), len: 360 aa. Probable chaA, ionic transporter integral membrane protein, putative calcium/proton antiporter, similar to many e.g. P31801|CHAA_ECOLI calcium/proton antiporter from Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0, (35.9% identity in 351 aa overlap). Equivalent to Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity in 364 aa overlap). Seems to belong to the CaCA family. |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1806181 | 1807263 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1607|chaA
MLKRVPWTVVLPSLAFVALVLTWGKQIGPVVGLLAAVLLAGAVLAAVNHAEVVAARVGEPFGSLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMITTNGIAGLSLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPELSPGQLIFAGAASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPSTRAALLSLGLLLVALVAVVGLAKVESPVIEEVVSAAGFPQSFVGVVIATLVLLPETLAAARAARQGRLQTSLNLAYGSAMASIGLTIPTIALASLWLSGPLQLGLGAIQLVLLVLTVVVSVLTVVPGRATRLQGEVHLVLLAAYLFLAVVP
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
