Gene Rv2024c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv2024c, (MTV018.11c), len: 515 aa. Conserved hypothetical protein. Identical to N-terminal part of much larger hypothetical protein, RvD1-Rv2024c' (1606 aa), from Mycobacterium bovis BCG: CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably truncated. Part of RvD1 chromosomal deletion region. |
| Functional category | Conserved hypotheticals |
| Proteomics | Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Essentialgene by Himar1 transposon mutagenesis in CDC1551 strain (see Lamichhane et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2268693 | 2270240 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2024c|Rv2024c
MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAVWWWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNLTPAKRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARILLLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESNFVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACLNSSRRIQA
Bibliography
- Brosch R et al. [1999]. Genomic analysis reveals variation between Mycobacterium tuberculosis H37Rv and the attenuated M. tuberculosis H37Ra strain. Gene
- Lamichhane G et al. [2003]. A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Mutant
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Kruh NA et al. [2010]. Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. Proteomics
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
