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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionPossibly involved in cAMP synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]
ProductAdenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase)
CommentsRv2212, (MTCY190.23), len: 378 aa. Adenylyl cyclase (See Abdel Motaal et al., 2006). Some similarity to e.g. SW:CYAA_STRCO P40135 adenylate cyclase (29.2% identity in 291 aa overlap); ttg at 24614 in MTCY190 has a better rbs. Contains possible helix-turn-helix motif at aa 64- 85, (+2.72 SD). Also similar to Rv1264 and Rv1647
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified by mass spectrometry in the culture filtrate and whole cell lysates of M. tuberculosis H37Rv but not the membrane protein fraction (See de Souza et al., 2011). Translational start site supported by proteomics data (See Kelkar et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS24771902478326+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2212|Rv2212
VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD