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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPossible toxin VapC48. Contains PIN domain.
CommentsRv3697c, (MTV025.045c), len: 145 aa. Possible vapC48, toxin, part of toxin-antitoxin (TA) operon with Rv3697A, contains PIN domain, see Arcus et al. 2005. Similar to many others in Mycobacterium tuberculosis e.g. Q10800|YS72_MYCTU|Rv2872|MT2939|MTCY274.03 (147 aa) FASTA scores: opt: 223, E(): 7.3e-08, (32.6% identity in 141 aa overlap); O53501|Rv2103c|MTV020.03 (144 aa), FASTA scores: opt: 215, E(): 2.4e-07, (31.4% identity in 137 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores: opt: 192, E(): 7.6e-06, (31.25% identity in 144 aa overlap); etc.
Functional categoryVirulence, detoxification, adaptation
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41398054140242-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3697c|vapC48
VSETFDVDVLVHATHRASPFHDKAKTLVERFLAGPGLVYLLWPVALGYLRVVTHPTLLGAPLAPEVAVENIEQFTSRPHVRQVGEANGFWPVYRRVADPVKPRGNLVPDAHLVALMRHHGIATIWSHDRDFRKFEGIRIRDPFSG