Gene Mb0804
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable protease ii ptrbb [second part] (oligopeptidase b) |
| Comments | Mb0804, ptrB, len: 719 aa. Equivalent to Rv0781 and Rv0782, len: 236 aa and 552 aa, from Mycobacterium tuberculosis strain H37Rv, (97.6% identity in 206 aa overlap and 100.0% identity in 517 aa overlap). Probable ptrB, protease II (EC 3.4.21.83), equivalent to NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar to C-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa),FASTA scores: opt: 204, E(): 7.4e-07, (29.6% identity in 230 aa overlap); etc. Also highly similar to N-termini of many proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II from Escherichia coli strains K12 and HB101 (707 aa), FASTA scores: opt: 1251, E(): 0, (42.7% identity in 489 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be a frameshifted homologues of protease II, but we can find no error in the cosmid sequence to account for this. BELONGS TO PEPTIDASE FAMILY S9A; ALSO KNOWN AS THE PROLYL OLIGOPEPTIDASE FAMILY. Note that previously known as ptrBb. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes,ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, a 2 bp insertion (*-gc) leads to a single product. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 876422 | 878581 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb0804|ptrB
MMHRTALPSPPVAKRVQTRREHHGDVFVDPYEWLRDKDSPEVIAYLEAENDYTERTTAHLEPLRQKIFHEIKARTKETDLSVPTRRGNWWYYARTFEGKQYGVHCRCPVTDPDDWNPPEFDERTEIPGEQLLLDENVEADGHDFFALGAASVSLDDNLLAYSVDVVGDERYTLRFKDLRTGEQYPDEIAGIGAGVTWAADNRTVYYTTVDAAWRPDTVWRYRLGSGESSERVYHEADDRFWLAVGRTRSNAYLLIAAGSSITSEVRYAHAADPTAQFSVVLPRRDGVEYSVEHAVIAGQDRFLILHNDGAVNFTLVEAPVEDPARQRTLIAHRDDVRLDAVDALAGHLVVSYRREALPRVQLWPIGPDGNYGEPEEISFDSELMSAGLGPNPNWDSPKLRVGAGSFVTPVRIYDIDLVTGERTLLKEQPVLGGYRREDYVERRDWAYGDDGTRIPVSIVHRADIEFPAPALIYGYGAYEICEDPRFSIARLSLLDRGMVFVVAHVRGGGEMGRLWYENGKLLDKKNTFTDFIAVARHLVDTGLTSQQQLVALGGSAGGLLMGAVANMAPDLFAGILAQVPFVDPLTTILDPSLPLTVTEWDEWGNPLNDSDVYAYVKSYSPYENVTAQKYPAILAMTSLNDTRVYYVEPAKWVAALRHAKTDGNSVLLKTQMHAGHGGISGRYERWKETAFQYGWLLATADSDRYGGGQGNDLDGAAPA
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