Gene Mb1579
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | probable fumarate reductase [membrane anchor subunit] frdc (fumarate dehydrogenase) (fumaric hydrogenase) |
| Comments | Mb1579, frdBC, len: 374 aa. Equivalent to Rv1553 (frdB) and Rv1554 (frdC), len: 247 aa and len: 126 aa,from Mycobacterium tuberculosis strain H37Rv, (100% identity in 247 aa overlap and 99.2% identity in 126 aa overlap). Probable frdB, fumarate reductase, iron-sulfur subunit (EC 1.3.99.1), highly similar to others e.g. P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein from Escherichia coli strain K12 (243 aa), FASTA scores: opt: 846, E(): 0, (50.0% identity in 242 aa overlap); P20921|FRDB_PROVU FUMARATE REDUCTASE IRON-SULFUR PROTEIN from Proteus vulgaris (245 aa); G64097 fumarate reductase (EC 1.3.99.1) iron-sulfur protein from Haemophilus influenzae (276 aa); etc. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. And probable frdC, fumarate reductase, membrane-anchor subunit (EC 1.3.99.1), highly similar to others e.g. P03805|FRDC_ECOLI fumarate reductase 15 kDa hydrophobic protein from Escherichia coli strain K12 (131 aa), FASTA scores, opt: 268, E(): 3.9e-10, (31.1% identity in 122 aa overlap); NP_458780.1|NC_003198 fumarate reductase complex subunit C; membrane anchor polypeptide from Salmonella enterica subsp. enterica serovar Typhi (131 aa); P20923|FRDC_PROVU FUMARATE REDUCTASE 15 KD HYDROPHOBIC PROTEIN from Proteus vulgaris (131 aa); etc. NOTE THAT FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR PROTEINS (Rv1554|frdC and Rv1555|frdD). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) leads to a single product. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1743450 | 1744574 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb1579|frdBC
MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKLLFPWGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLVLVLRAVGAGGNSYQRFLDFSANPVVVVLNVVALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHYAAWLVVSVIVAWMVLS
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